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Monitor Closely (one)lumefantrine will lessen the level or influence of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. For patients getting exemestane having a powerful CYP3A4 inducer the suggested dose of exemestane is 50 mg everyday following a food.Aromasin includes the active drug exemestane. Arimidex